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Fragile x syndrome

What is Fragile X Syndrome? - YouTube

Fragile X syndrome - Genetics Home Reference - NI

Sindrome dell'X fragile - Wikipedi

  1. Fragile X syndrome is a genetic disorder caused by a change to one of the genes on the X chromosome. It is the most common inherited cause of intellectual disability. Fragile X syndrome is also linked to features of autism spectrum disorder. Fragile X syndrome affects around 1 in 3,600 boys and between 1 in 4,000 - 6,000 girls
  2. Fragile X syndrome. Fragile X syndrome is the leading cause of inherited intellectual disability, affecting about 1 in 4,000 males and about 1 in 6,000 females. Both males and females can be carriers of the Fragile X gene alteration, and are called premutation carriers. About 1 in 250 women and 1 in 800 men are Fragile X premutation carriers
  3. Fragile X Disorders. Fragile X-associated disorders (FXD) is a family of genetic conditions that can affect individuals in a variety of ways. The conditions are all caused by changes in the gene known as FMR1.Fragile X Syndrome (FXS) is caused by a full mutation of the FMR1 gene

Fragile X syndrome is one of the most common forms of inherited intellectual disability, affecting 1 in 5,000 males 1.The vast majority of cases are caused by the expansion of a CGG-trinucleotide repeat in the 5′ untranslated region of the X-linked FMR1 gene 2.This results in the gene not being expressed and the absence of the encoded FMRP protein Information about Fragile X . Fragile X Syndrome is the most common known inherited cause of learning disabilities, affecting around 1 in 4000 males and 1 in 8000 females. It can cause a wide range of difficulties with learning, as well as social, language, attentional, emotional, and behavioral problems La sindrome dell'X fragile è conosciuta anche con l'acronimo FXS - che sta per Fragile X Syndrome - e con il nome di sindrome di Martin-Bell. EPIDEMIOLOGIA. La sindrome dell'X fragile è più comune tra i soggetti di sesso maschile Fragile X syndrome (FXS) is an inherited genetic disease passed down from parents to children that causes intellectual and developmental disabilities. It's also known as Martin-Bell syndrome Fragile X syndrome (FXS) is the most common inherited cause of autism and intellectual disabilities. It affects 1 in 4,000 boys and 1 in 6,000 girls worldwide. Fragile X syndrome occurs when a single gene on the X chromosome shuts down. This gene makes a protein needed for normal brain development

About Fragile X Syndrome

Living with Fragile X syndrome Although there is no cure for Fragile X, treatments (including some medications) can help improve quality of life, especially if received early on. Ideally, each person with Fragile X will be cared for by a multidisciplinary team of health professionals Le syndrome de l'X fragile (également appelé syndrome de Martin et Bell ou syndrome d'Escalante ; en anglais, fragile X syndrome ou FXS) est un syndrome génétique. C'est une cause fréquente de retard cognitif.. Il peut donner des caractéristiques physiques comme un visage allongé, des oreilles larges et décollées, de gros testicules (macro-orchidie) In people with fragile X syndrome, however, the CGG segment is repeated more than 200 times. The abnormally expanded CGG segment inactivates (silences) the FMR1 gene, which prevents the gene from producing a protein called fragile X mental retardation protein. Loss of this protein leads to the signs and symptoms of fragile X syndrome La Sindrome dell'X Fragile è una condizione genetica ereditaria, cioè si trasmette dai genitori ai figli, ed è causa di disabilità cognitiva, problemi di apprendimento e relazionali. Si presenta sia nei maschi che nelle femmine e i sintomi si presentano in maniera più evidente nei maschi. L'incidenza è stimata in 1 caso su 4000 maschi e 1 su 7000 femmine Fragile X syndrome (FXS) is a genetic disorder. A genetic disorder means that there are changes to the person's genes. FXS is caused by changes in the fragile X mental retardation 1 (FMR1) gene. The FMR1 gene usually makes a protein called fragile X mental retardation protein (FMRP). FMRP is needed for normal brain development

The National Fragile X Foundation Fragile X Syndrome

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  2. This is the first in a series of new educational videos about Fragile X Syndrome, the most common inherited cause of learning disability. The video covers an introduction to behavioural and health.
  3. Fragile X syndrome (FXS) is the most common known genetic cause of inherited intellectual disability and the most common known single-gene cause of autism spectrum disorder. It has been reported that a spectrum of medical problems are commonly experienced by people with FXS, such as otitis media, seizures, and gastrointestinal problems
  4. Fragile X Syndrome Definition Fragile X syndrome is the most common form of inherited mental retardation. Individuals with this condition have developmental delay, variable levels of mental retardation, and behavioral and emotional difficulties. They may also have characteristic physical traits. Generally, males are affected with moderate mental.
  5. Fragile X syndrome can be a cause of autism or related disorders, although not all children with fragile X syndrome have these conditions. Prevention Genetic counseling may be helpful if you have a family history of this syndrome and are planning to become pregnant

Fragile X syndrome, an X-linked dominant disorder with reduced penetrance, is associated with intellectual and emotional disabilities ranging from learning problems to mental retardation, and mood. Fragile X Association of Australia is a registered charity, funded by donations and fundraising. Donations of $2.00 and over are tax deductible. Your donation will help us support families affected by Fragile X, and to increase awareness of Fragile X associated conditions. Make a donatio Fragile X syndrome is the most common form of inherited developmental disability.A problem with a specific gene causes the disease. Normally, the gene makes a protein you need for brain development

Fragile X syndrome is a rare or orphan disease which affects 1 in 4000 males and 1 in 6000 females. It occurs when a single gene, FMR1, on the long arm of the X chromosome, shuts down and fails to produce a protein, FMRP, which is vital for normal brain development Fragile X Syndrome (FXS, OMIM # 309550) is an X-linked disease that is primarily based on the genomic expansion of a triplet of nucleotides (CGG), and aberrant methylation of the promoter region. The expansion is located in the 5' untranslated region of the FMR1 gene.

This video contains information about the causes of Fragile X Syndrome. Comments on this video are allowed in accordance with our comment policy:. Fragile X syndrome (also called Fragile X) is the most common inherited form of mental problems (mental retardation).; Fragile X syndrome is caused by changes in a single X chromosome (FMR1).FMR1 does not produce enough protein (FMRP) that works cell communication.; Normal X genes that control FMR1 levels have promoter regions consisting of about 6 to 40 CGG; Fragile X genes have about 55 to. La sindrome dell'X fragile, o sindrome di Martin-Bell, è una malattia genetica causata dalla mutazione del gene FMR1 sul cromosoma X. Questa sindrome è la causa più frequente del ritardo mentale ereditario.Si accompagna normalmente a un lieve dimorfismo, disturbi del comportamento e macrorchidismo nei maschi. L'incidenza della patologia è di circa 1 su 1250 soggetti di sesso maschile, e. Fragile X syndrome is characterized by developmental problems including intellectual disability and delayed speech and language development. Males are usually more severely affected than females. Additional features may include anxiety; attention deficit disorder (ADD); features of autism spectrum disorders that affect communication and social interaction; and seizures

Fragile X Syndrome: Symptoms, Causes, Diagnosis, and Treatmen

Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability worldwide. It is caused by a mutation of the FMR-1 (fragile-X mental retardation) gene located on the X chromosome. This contribution explores the genetic and molecular basis of the disease and methods for its detection, as well as neuropathological findings Fragile X is the most common, known single-gene cause of ASD. Fragile X affects more boys than girls and also affects boys more severely than girls. Fragile X appears in children of all cultures and ethnic backgrounds. Fragile X carriers People can be carriers of Fragile X syndrome without having the condition themselves While the life span of people with fragile X syndrome (FXS) is typically normal, there is very little information in the medical literature about adults with FXS. The effect of specific medical problems or associated complications on adults with FXS may vary because not all affected people have the same features Triple X syndrome is also called 47,XXX syndrome because the extra X chromosome results in 47 chromosomes in each cell instead of the usual 46. Complications Although some females may have mild or no symptoms associated with triple X syndrome, other girls and women experience developmental, psychological and behavioral problems that may lead to a variety of other issues, including Fragile X syndrome (FXS) is the leading inherited form of intellectual disability and autism spectrum disorder, and patients can present with severe behavioural alterations, including.

What is Fragile X syndrome? Fragile X is a genetic condition that affects both boys and girls, although boys are often more severely affected. It can cause a range of issues with language, emotions, attention, behaviour and social interaction. Fragile X and learning disability. Fragile X is the most common inherited cause of learning disability Fragile X syndrome (FXS), first known as Martin-Bell syndrome, is the most common inherited form of mental impairment. FXS affects 1 in 4,000 boys and 1 in 6,000 girls of all races and ethnic groups. While Fragile X individuals have a normal life expectancy, most will need support and care for their entire lives Fragile X syndrome is the most common cause of inherited intellectual disability, affecting an estimated 1.4 in 10,000 males and 0.9 in 10,000 females, according to the Centers for Disease Control. Fragile X syndrome is a genetic condition inherited in an X-linked dominant pattern. It is usually due to the expansion of the CGG triplet repeat (trinucleotide repeat) within the Fragile X Mental Retardation 1 (FMR1) gene present on the X chromosome. Diagnosis can be achieved through genetic testing

What is Fragile X Syndrome (FXS)? CD

Epigenetics May Provide Relief for Fragile X Syndrome and

As mentioned above, fragile X syndrome is caused by a mutation in the FMR1 gene located on the X chromosome at Xq27.3. Individuals with fragile X syndrome nearly always have (in greater than 99% of cases) a full mutation of the FMR1 gene which means that they have over 200 CGG repeats and abnormal methylation of the gene.Methylation is a chemical change to the DNA that carries the genetic code. Das Fragiles-X-Syndrom (FXS) ist eine der häufigsten Ursachen erblicher kognitiver Behinderung des Menschen. Ursache hierfür ist eine genetische Veränderung auf dem X-Chromosom, die Mutation eines expandierenden Trinukleotidrepeats im Gen FMR1 (fragile X mental retardation 1).Die Behinderung, die zu den X-chromosomalen mentalen Retardierungen gezählt wird, kann in ihrer Schwere stark.

Fragile X syndrome : diagnosis, treatment, and research

Fragile X syndrome definition is - an X-linked inherited disorder that is characterized especially by moderate to severe intellectual and developmental disabilities, an elongated face and prominent forehead, chin, and ears, and by large testes in males, and that often has limited or no effect in heterozygous females. How to use fragile X syndrome in a sentence fragile x syndrome happens because of genetic problems. the fmr1 gene normally makes a protein called fmr that helps nerve cells talk to one another Fragile X syndrome is a medical condition that causes intellectual disability and other medical problems. It is the most common kind of genetically inherited intellectual disability, and the second-most common type of intellectual disability overall (after Down syndrome).Fragile X syndrome is estimated to occur in about one male in 5,000 to 7,000 and in about one female in 4,000 to 6,000

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Fragile X News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment The syndrome may affect the ability to think, reason, and learn. Because many people with Fragile X also have attention disorders, hyperactivity, anxiety, and language-processing problems, a person with Fragile X may have more capabilities than his or her IQ (intelligence quotient) score suggests. Physical

How is Fragile X syndrome inherited? The gene for Fragile X is carried on the X chromosome. Because both males (XY) and females (XX) have at least one X chromosome, both can pass on the mutated gene to their children. A father with the altered gene for Fragile X on his X chromosome will pass that gene on only to his daughters Fragile X syndrome is seen in approximately 1 in 4,000 to 6,000 males and 1 in 8,000 to 9,000 females. However, many more people carry the fragile X pre-mutation, but show no signs or symptoms of the syndrome. Fragile X syndrome is the most common inherited cause of mental retardation in males. Symptoms. Signs and symptoms vary and can include Fragile X syndrome is caused by an expansion of CGG nucleotide repeats in the FMR1 gene at the end of the long arms of the X chromosome. To identify the mutation, researchers culture cells in media deficient in folic acid, which causes the ends of the X chromosome to appear as though they are about to break off

Mary Nuttall: "Breeders Beware of Warmblood Fragile Foal

Fragile X syndrome - Better Health Channe

Understanding Fragile X - Fragile X Association of Australi

Fragile X syndrome (FXS) is one of the more common known causes of intellectual disability that can run in families (inherited). FXS is caused by a change in the genetic material in each cell of the body T1 - Fragile X Syndrome. AU - Schwarte, Andrea R. PY - 2008/6/1. Y1 - 2008/6/1. N2 - This article provides an overview of current research on Fragile × Syndrome, and how that knowledge can be used to guide successful intervention Fragile X Syndrome (FXS) is a genetic condition that causes learning/intellectual disability, anxiety, behavioural and learning challenges, delayed development, speech and communication challenges, sensory sensitivities and autistic like behaviours. Strengths include strong imitation skills, good memory and great sense of humour Fragile X syndrome (FXS), an X-linked condition first described by Martin and Bell (), is the leading cause of inherited intellectual disability (ID).Estimates report that FXS affects approximately 1 in 2,500 to 5,000 men and 1 in 4,000 to 6,000 women (2, 3).FXS is caused by mutations in the FMR1 gene, which is located on the X chromosome and whose locus at Xq27.3 coincides with the folate.

La sindrome dell'X fragile, o sindrome di Martin-Bell, è una malattia genetica causata dalla mutazione del gene FMR1 sul cromosoma X. Questa sindrome è la causa più frequente del ritardo mentale ereditario. Si accompagna normalmente a un lieve dimorfismo, disturbi del comportamento e macrorchidismo nei maschi. L'incidenza della patologia è di circa 1 su 1250 soggetti di sesso maschile, 1. Fragile X syndrome is the world's leading cause of inherited intellectual disability. It is also the leading identifiable cause of autism. About 6% of autistic people turn out to have fragile X and 50% of pre-school fragile children meet the diagnostic criteria for autism Welcome to the Irish Fragile X Society (IFXS) Online. Welcome to the Irish Fragile X Society (IFXS) online. We hope you will find this site informative and helpful, whether you are a parent/carer, a teacher, or other professional working with an individual affected by Fragile X syndrome

Fragile X 101 The Three Fragile X Disorder

Fragile X Syndrome (FXS, OMIM #300624), also known as Martin-Bell Syndrome, was first described in 1943 by Martin and Bell as a form of intellectual disability (ID) following an X-linked inheritance pattern [].In 1969, Lubs first reported a distinct fragile site on the X chromosome that segregated with ID in 3 generations of a family, and in 1991, the association of the Xq27.3 fragile site. Fragile X syndrome (FXS) is the leading known inherited cause of intellectual disability and autism spectrum disorders (ASDs). Over 100,000 Americans have FXS; moreover, it is estimated that over one million are Fragile X carriers Fragile X syndrome is the most common inherited cause of cognitive impairment in males. It is named for the folate sensitive fragile site Xq27.3 and is caused by an expansion or amplification of a CGG trinucleotide repeat in the first exon of the fragile X mental retardation gene ( FMR1 ), located on the long arm of the X chromosome

A number sign (#) is used with this entry because fragile X (FXS) is caused by mutation in the FMR1 gene ().The vast majority of cases are caused by a trinucleotide (CGG)n repeat expansion (309550.0004) of greater than 200 repeats.See also fragile X tremor/ataxia syndrome (FXTAS; 300623), which is caused by expanded FMR1 (CGG)n repeats that range in size from 55 to 200 repeats and are referred. Fragile-X syndrome (also called FXS) is a human chromosomal disorder associated with a fragile site on the end of the X chromosome.The disorder is the most common cause of inherited intellectual disability and is associated with a range of developmental delays as well as behavioral and learning challenges. Fragile-X syndrome affects both males and females, but the syndrome is more common in. Fragile X syndrome (FXS) is a genetic condition that shows typical physical attributes along with behavioural and developmental anomalies in children. It is also called Martin Bell syndrome or a. However, in fragile X syndrome, the methylation of the FMR1 gene turns the gene off when it should be turned on. When FMR1 is turned off, its protein is not made, and you see the features of fragile X syndrome. When someone with fragile X syndrome has methylation mosaicism, not all cells will have the FMR1 gene turned off by methylation

Advances in the treatment of fragile x Syndrome Randi J. Hagerman, Elizabeth Berry-Kravis, Walter E. Kaufmann, Michele Y. Ono, Nicole Tartaglia, Ave Lachiewicz, Rebecca Kronk, Carol Delahunty, David Hessl, Jeannie Visootsak, Jonathan Picker, Louise Gane, Michael Tranfagli Fragile X Syndrome FXS is a rare genetic condition that causes intellectual disability, anxiety disorders, social avoidance, behavioral and learning challenges and various physical characteristics. It is the leading known genetic cause of both inherited intellectual disability and autism spectrum disorder. The behavioral symptoms of FXS are linked to deficiencies in the endocannabinoid (EC.

Fragile X-associated disorders are a family of X-linked genetic conditions caused by expansions of a cytosine-guanine-guanine (CGG) repetitive sequence in the Fragile X Mental Retardation 1 (FMR1) gene.Full mutation (>200 CGG repeats) of the FMR1 gene results in fragile X syndrome (FXS), 1 the most common known inherited cause of intellectual disability SYNDROME X-FRAGILE et SUIVI MEDICAL from Filière DéfiScience on Vimeo.. Actuellement, aucun traitement n'est disponible pour guérir le syndrome de l'X fragile.Le syndrome de l'X fragile demande une prise en charge multidisciplinaire (kinésithérapie, psychomotricité, orthophonie / logopédie, ergothérapie, ) et socio-éducative spécifique (classes d'enseignement adapté) Background Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. The aim of our longitudinal study was to describe ageing‐related cognitive changes in men with FXS Fragile X syndrome (FXS) is a genetic syndrome that causes a range of intellectual disabilities as well as unusual physical and behavioural characteristics. It is one of the most common causes of autism and mental retardation among boys. Basically, these individuals lack an important gene product.. Technical account. Fragile X syndrome occurs as a result of a mutation of the FMR1 gene on the X.

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CHE COS'È La sindrome della X Fragile, anche conosciuta come sindrome di Martin-Bell, è una rara condizione genetica ereditaria, caratterizzata da ritardo globale dello sviluppo (ritardo neuropsicomotorio), disabilità intellettiva più o meno grave, disturbi dell'apprendimento e della capacità di relazionarsi con gli altri.Interessa prevalentemente il sesso maschile, più raramente quello. The Fragile X Alliance Inc is a non-profit organisation whose mission statement is to promote education and research into fragile X syndrome, as well as disseminate information and new findings about fragile X syndrome. Specifically, FXA Inc offer clinical services and educational resources Fragile X Syndrome (FXS) is the most common inherited form of mental retardation. Symptoms, which are typically milder in females than in males, include behavioral and/or emotional problems (including autistic-like features) and varying degrees of mental impairment

Fragile X Syndrome. Related Gene(s): FMR1. Fragile X syndrome affects approximately 1 in 1250 males and 1 in 2000 females, making it the single most common form of inherited mental retardation. It is caused by expansion of the trinucleotide CGG repeat in the 5' untranslated portion of the FMR1 gene on the X chromosome 5 Contact us Floor, Borough Wing, Guy's Hospital, Great Maze Pond, London SE1 9RT t: 020 7188 1364, f: 020 7188 1369 department. Fragile X syndrome Fragile X syndrome can be a cause of autism or related disorders, although not all children with fragile X syndrome have these conditions. Prevention. Genetic counseling may be helpful if you have a family history of this syndrome and are planning to become pregnant. References. Saul RA, Tarleton JC. FMR1-related disorders. GeneReviews. 2012:4

Diagnosis. Initially, Fragile X syndrome was diagnosed by karyotyping cells in a folate-deficient medium to look for the fragile site on the X chromosome (thus leading to the disease's name). The current gold standard for diagnosis is either PCR or Southern blot analysis. There have been pilot studies for inclusion of Fragile X syndrome in newborn screening, however it is not currently included La sindrome X fragile (o sindrome di Martin-Bell) è la causa ereditaria più frequente di disabilità apprendimento. Uno dei geni sul cromosoma X è difettoso, causa dell'espansione di ripetizione trinucleotidica CGG all'interno del gene FMR1. Sintomi e segni portano a diagnosi genetic Fragile X syndrome is the most common form of inherited developmental disability. A problem with a specific gene causes the disease. Normally, the gene makes a protein you need for brain development. But the problem causes a person to make little or none of the protein. This causes the symptoms of Fragile X Fragile X syndrome is a hereditary disorder affecting mostly males. Symptoms include mental retardation, distinctive facial features, and poor muscle tone. The syndrome is caused by mutations in a gene on the X chromosome. Since males have a single copy of the X chromosome, they show symptoms if gene on their X chromosome is mutated Fragile X syndrome occurs with a frequency of approximately 1 in 4000 males and 1 in 8000 females. Affected males will exhibit moderate to severe mental retardation as well as a speech delay, hyperactivity, and behavioral and social difficulties. Fragile X syndrome results from the expansion of a CGG trinucleotide repeat in the FMR1 gene which.

Fragile X syndrome Spectrum Autism Research New

Fragile X syndrome can be detected by DNA tests done after birth. The diagnosis of Fragile X syndrome is typically made when the child is school age or an adolescent. Boys with autism and intellectual disability should be tested for Fragile X syndrome, especially if their mother has relatives who have similar problems More Fragile-X Syndrome animations & videos Research about Fragile-X Syndrome. Visit our research pages for current research about Fragile-X Syndrome treatments.. Clinical Trials for Fragile-X Syndrome. The US based website ClinicalTrials.gov lists information on both federally and privately supported clinical trials using human volunteers Fragile X syndrome inheritance. Fragile X syndrome is inherited in an X-linked dominant pattern. A condition is considered X-linked if the mutated gene that causes the disorder is located on the X chromosome, one of the two sex chromosomes Fragile X syndrome (FXS) is an X-linked disorder and the most common inherited cause of intellectual disability . Both males and females can be affected. The clinical features and diagnosis of FXS (previously called fragile X mental retardation syndrome, X-linked mental retardation and macro-orchidism, and Martin-Bell syndrome) in children and adolescents are discussed in this topic review People with Fragile x Syndrome have intellectual disability, behavioural and learning challenges, as well as certain physical characteristics; Depending on how an individual's FMR1 gene has been changed by Fragile X Syndrome depends whether they show symptoms of Fragile X or are carriers with no symptom

Syndromes by Pictures - Medical Genetics 2017 with Richer

For people with fragile X syndrome, progress in daily living skills and behavior tends to stall later in life, according to a new study 1. And weight gain is a common health issue. The study is the first to track the long-term course of fragile X syndrome , by following people with the condition for nearly a decade Fragile X syndrome is a genetic disorder that affects a person's development, especially that person's behavior and ability to learn. In addition, Fragile X can affect communication skills, physical appearance, and sensitivity to noise, light, or similar information People with Fragile X syndrome (or Fragile X) have intellectual disability, behavioural and learning challenges as well as certain physical characteristics. Fragile X is the most common inherited cause of intellectual disability, and also the most common genetic cause of autism. It affects around one in 3600 males and around one in 6000 females Fragile X syndrome in males is usually more severe than in females and males are never asymptomatic.This is because males have only one X chromosome (unlike females that have 2 X chromosomes) and therefore any defect on the X chromosome is likely to be displayed

About Fragile X Syndrome - Fragile X Fragile X Societ

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Fragile X syndrome or Martin-Bell syndrome is a syndrome of X-linked mental retardation which results in a spectrum of characteristic physical, intellectual, emotional and behavioural features which range from severe to mild in manifestation.. The syndrome is associated with the expansion of a single trinucleotide gene sequence (CGG) on the X chromosome, and results in a failure to express the. Researchers administered the test to 106 individuals with Fragile X syndrome and intellectual disability, from ages 6 to 23. Participants took the test once and again four weeks later. Test score were consistent across both versions, which showed that the test was reliable Fragile X syndrome (FXS) is the most common inherited form of mental impairment and autism, and one of many types of intellectual dysfunction associated with gene defects in the X chromosome. The first clinical description of FXS by Martin and Bell dates back to 1943, while its association with a fragile site on the X chromosome was established in 1969 Fragile X syndrome is the most common inherited form of mental retardation. It's caused by a mutation on the X chromosome. People with Fragile X syndrome suffer from physical, social, emotional, speech, language, sensory, intelligence, and learning impairments

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